Identification of EGFRvIII-derived CTL Epitopes Restricted by HLA A0201 for Dendritic Cell Based Immunotherapy of Gliomas

@article{Wu2005IdentificationOE,
  title={Identification of EGFRvIII-derived CTL Epitopes Restricted by HLA A0201 for Dendritic Cell Based Immunotherapy of Gliomas},
  author={An-Hua Wu and Jing Xiao and Lars Anker and Walter A. Hall and Dale S Gregerson and Webster K Cavenee and Wei Chen and Walter C. Low},
  journal={Journal of Neuro-Oncology},
  year={2005},
  volume={76},
  pages={23-30}
}
The type III variant of the epidermal growth factor receptor (EGFRvIII) mutation is present in 20–25% of patients with glioblastoma multiforme (GBM). EGFRvIII is not expressed in normal tissue and is therefore a suitable candidate antigen for dendritic cell (DC) based immunotherapy of GBM. To identify the antigenic epitope(s) that may serve as targets for EGFRvIII-specific cytotoxic T lymphocytes (CTLs), the peptide sequence of EGFRvIII was screened with two software programs to predict… CONTINUE READING