Identification of EBV transforming genes by recombinant EBV technology.

  title={Identification of EBV transforming genes by recombinant EBV technology.},
  author={Kenneth M Izumi},
  journal={Seminars in cancer biology},
  volume={11 6},
Epstein-Barr virus (EBV) is able to infect primary B-lymphocytes but usually does not proceed to replicate more virions. Instead, EBV persists as an incomplete virus and expresses 12 gene products that transform the growth of these cells into continuously proliferating lymphoblastoid cell lines. Because EBV is associated with several human malignancies, there is intense interest in delineating the molecular functions of these EBV gene products in transformation. This review focuses on the… CONTINUE READING

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