Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-terminal region

@article{He2000IdentificationOE,
  title={Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-terminal region},
  author={Yiwen He and Michael K Armanious and Matthew J Thomas and W. Douglas Cress},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={3422-3433}
}
We have identified a novel form of the full-length E2F-3 protein that we term E2F-3B. In contrast to full-length E2F-3, which is expressed only at the G1/S boundary, E2F-3B is detected throughout the cell cycle with peak levels in G0 where it is associated with Rb. Transfection and in vitro translation experiments demonstrate that a protein identical to E2F-3B in size and iso-electric point is produced from the E2F-3 mRNA via the use of an alternative translational start site. This alternative… CONTINUE READING