Identification of Differential Protein Expression in Hepatocellular Carcinoma Induced Wistar Albino Rats by 2D Electrophoresis and MALDI-TOF–MS Analysis

@article{Vedarethinam2015IdentificationOD,
  title={Identification of Differential Protein Expression in Hepatocellular Carcinoma Induced Wistar Albino Rats by 2D Electrophoresis and MALDI-TOF–MS Analysis},
  author={Vadanasundari Vedarethinam and Karthik Dhanaraj and Ilavenil Soundherrajan and Ravikumar Sivanesan},
  journal={Indian Journal of Clinical Biochemistry},
  year={2015},
  volume={31},
  pages={194-202}
}
Hepato cellular carcinoma (HCC) is a type of malignant tumor. To investigate the proteins in cancer molecular mechanism and its role in HCC, we have used proteomic tools such as 2DE and MALDI-TOF–MS. Our investigation ravels that, plasma α-fetoprotein and carcinoembryonic antigen levels were elevated in DEN induced rats and gradually decreased after the treatment with 1,3BPMU. 2DE and MALDI-TOF–MS tool offers to identify the up and down regulation of proteins in HCC. Proteomic study reveals… CONTINUE READING