Identification of Differential Methylation of the WT 1 Antisense Regulatory Region and Relaxation of Imprinting in Wilms ’ Tumor 1

Abstract

Wilms’ tumor (WT) is associated with loss of heterozygosity at chromosome 11p13, the site of the Wilms’ tumor suppressor gene, WT1. Although the preferential loss of maternal alleles suggested that differential allelic expression of WT1 might occur, this has not been evident in normal fetal tissues or WTs. In this study, we show that the WT1 antisense… (More)

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