Identification of Der p 23, a peritrophin-like protein, as a new major Dermatophagoides pteronyssinus allergen associated with the peritrophic matrix of mite fecal pellets.

@article{Weghofer2013IdentificationOD,
  title={Identification of Der p 23, a peritrophin-like protein, as a new major Dermatophagoides pteronyssinus allergen associated with the peritrophic matrix of mite fecal pellets.},
  author={Margit Weghofer and Monika Grote and Yvonne Resch and Anne Casset and Michael Kneidinger and Jolanta Kopec and Wayne Robert Thomas and Enrique Fern{\'a}ndez-Caldas and Michael Kabesch and Rosetta Ferrara and Adriano Mari and Ashok Purohit and Gabrielle Pauli and Friedrich Horak and Walter Keller and Peter Valent and Rudolf Valenta and Susanne Vrtala},
  journal={Journal of immunology},
  year={2013},
  volume={190 7},
  pages={3059-67}
}
The house dust mite (HDM) Dermatophagoides pteronyssinus is one of most important allergen sources and a major elicitor of allergic asthma. We screened a D. pteronyssinus expression cDNA library with IgE Abs from HDM allergic patients. A cDNA coding for a new major allergen was isolated, which showed sequence homology to peritrophins, which contain chitin-binding domains and are part of the peritrophic matrix lining the gut of arthropods. The mature Der p 23 allergen was expressed in… CONTINUE READING