Identification of DNA sequences flanking the breakpoint of human t(14q21q) Robertsonian translocations.

@article{Earle1992IdentificationOD,
  title={Identification of DNA sequences flanking the breakpoint of human t(14q21q) Robertsonian translocations.},
  author={Elizabeth Earle and Lisa Gail Shaffer and Paul Kalitsis and C. I. McQuillan and Sue Dale and K. H. Choo},
  journal={American journal of human genetics},
  year={1992},
  volume={50 4},
  pages={717-24}
}
We have employed molecular probes and in situ hybridization to investigate the DNA sequences flanking the breakpoint of a group of t(14q21q) Robertsonian translocations. In all the families studied, the probands were patients with Down syndrome who carried a de novo t(14q21q) translocation. The DNA probes used were two alphoid sequences, alphaRI and alphaXT, which are specific for the centromeres of chromosomes 13 and 21 and of chromosomes 14 and 22, respectively; a satellite III sequence, pTRS… CONTINUE READING

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