Identification of DNA methylation-driven genes in esophageal squamous cell carcinoma: a study based on The Cancer Genome Atlas

@article{Lu2019IdentificationOD,
  title={Identification of DNA methylation-driven genes in esophageal squamous cell carcinoma: a study based on The Cancer Genome Atlas},
  author={T. Lu and D. Chen and Y. Wang and X. Sun and S. Li and Shuncheng Miao and Y. Wo and Y. Dong and Xiaoliang Leng and Wenxing Du and Wenjie Jiao},
  journal={Cancer Cell International},
  year={2019},
  volume={19}
}
  • T. Lu, D. Chen, +8 authors Wenjie Jiao
  • Published 2019
  • Biology, Medicine
  • Cancer Cell International
  • BackgroundAberrant DNA methylations are significantly associated with esophageal squamous cell carcinoma (ESCC). In this study, we aimed to investigate the DNA methylation-driven genes in ESCC by integrative bioinformatics analysis.MethodsData of DNA methylation and transcriptome profiling were downloaded from TCGA database. DNA methylation-driven genes were obtained by methylmix R package. David database and ConsensusPathDB were used to perform gene ontology (GO) analysis and pathway analysis… CONTINUE READING
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