Identification of DNA gyrase A mutations in ciprofloxacin-resistant isolates of Salmonella typhimurium from men and cattle in Germany.

@article{Heisig1995IdentificationOD,
  title={Identification of DNA gyrase A mutations in ciprofloxacin-resistant isolates of Salmonella typhimurium from men and cattle in Germany.},
  author={Peter Heisig and Benita Kratz and Elke Halle and Yvonne Gr{\"a}ser and Martin Altwegg and Wolfgang Rabsch and J. P. Faber},
  journal={Microbial drug resistance},
  year={1995},
  volume={1 3},
  pages={211-8}
}
Six multiply resistant isolates of Salmonella typhimurium var. copenhagen with high-level resistance to fluoroquinolones (e.g., MIC of ciprofloxacin: 32 micrograms/ml) were isolated from human patients (n = 3) and from cattle (n = 3). The isolates were examined by complementation tests using a set of broad-host-range plasmids, which carry either the gyrA+ or the gyrB+ genes or a combination of both from Escherichia coli K-12. The results indicated a combination of gyrA and gyrB mutations in all… CONTINUE READING