Identification of DNA basepairing via tunnel-current decay.

  title={Identification of DNA basepairing via tunnel-current decay.},
  author={Jin He and Lisha Lin and Peiming Zhang and Stuart Lindsay},
  journal={Nano letters},
  volume={7 12},
We propose a new approach for reading the sequence of a DNA molecule passing between electrodes on a nanopore, using hydrogen bond-mediated tunneling signals. The base-electrode interaction is modeled using a nucleo-base-functionalized STM probe that is pulled away from a nucleoside monolayer. Watson-Crick recognition results in slow decay of the tunnel current, which is uniquely characteristic of the basepair in over half the reads. Thirteen independent reads would yield the desired 99.99… 

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