Identification of DHX33 as a mediator of rRNA synthesis and cell growth.

  title={Identification of DHX33 as a mediator of rRNA synthesis and cell growth.},
  author={Yandong Zhang and Jason T. Forys and Alexander P. Miceli and Abigail S. Gwinn and Jason D. Weber},
  journal={Molecular and cellular biology},
  volume={31 23},
In this report, we employed a lentiviral RNA interference screen to discover nucleolar DEAD/DEAH-box helicases involved in RNA polymerase I (Pol I)-mediated transcriptional activity. Our screen identified DHX33 as an important modulator of 47S rRNA transcription. We show that DHX33 is a cell cycle-regulated nucleolar protein that associates with ribosomal DNA (rDNA) loci, where it interacts with the RNA Pol I transcription factor upstream binding factor (UBF). DHX33 knockdown decreased the… CONTINUE READING


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