Identification of DES1 as a Vitamin A Isomerase in Müller Glial Cells of the Retina

  title={Identification of DES1 as a Vitamin A Isomerase in M{\"u}ller Glial Cells of the Retina},
  author={Joanna J. Kaylor and Quan Yuan and Jeremy D. Cook and Shanta Sarfare and Jacob Makshanoff and Anh Miu and Anita Kim and Paul E. Kim and Samer I Habib and C. Nathaniel Roybal and Tongzhou Xu and Steven Nusinowitz and Gabriel H. Travis},
  booktitle={Nature chemical biology},
Absorption of a light particle by an opsin-pigment causes photoisomerization of its retinaldehyde chromophore. Restoration of light sensitivity to the resulting apo-opsin requires chemical re-isomerization of the photobleached chromophore. This is carried out by a multistep enzyme pathway called the visual cycle. Accumulating evidence suggests the existence of an alternative visual cycle for regenerating opsins in daylight. Here we identified dihydroceramide desaturase-1 (DES1) as a retinol… CONTINUE READING
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