Identification of Cytochrome P450 2E1 as the Predominant Enzyme Catalyzing Human Liver Microsomal Defluorination of Sevoflurane, Isoflurane, and Methoxyflurane

@article{Kharasch1993IdentificationOC,
  title={Identification of Cytochrome P450 2E1 as the Predominant Enzyme Catalyzing Human Liver Microsomal Defluorination of Sevoflurane, Isoflurane, and Methoxyflurane},
  author={E. Kharasch and K. Thummel},
  journal={Anesthesiology},
  year={1993},
  volume={79},
  pages={795–807}
}
  • E. Kharasch, K. Thummel
  • Published 1993
  • Medicine
  • Anesthesiology
  • BackgroundRenal and hepatic toxicity of the fluorinated ether volatile anesthetics is caused by biotransformation to toxic metabolites. Metabolism also contributes significantly to the elimination pharmacokinetics of some volatile agents. Although innumerable studies have explored anesthetic metabolism in animals, there is little information on human volatile anesthetic metabolism with respect to comparative rates or the identity of the enzymes responsible for defluorination. The first purpose… CONTINUE READING
    Metabolism of chloroform in the human liver and identification of the competent P450s.
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