Identification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein-protein interaction.

@article{Cardoso2012IdentificationOC,
  title={Identification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein-protein interaction.},
  author={Rosa M F Cardoso and Robert Love and Carol L. Nilsson and Simon Bergqvist and Dawn M. Nowlin and Jiangli Yan and Kevin K. Liu and Jing Zhu and Ping Ho Chen and Ya-li Deng and H Jane Dyson and Michael J. Greig and Alexei Brooun},
  journal={Protein science : a publication of the Protein Society},
  year={2012},
  volume={21 12},
  pages={1885-96}
}
The heterodimer HIF-1α (hypoxia inducible factor)/HIF-β (also known as ARNT-aryl hydrocarbon nuclear translocator) is a key mediator of cellular response to hypoxia. The interaction between these monomer units can be modified by the action of small molecules in the binding interface between their C-terminal heterodimerization (PasB) domains. Taking… CONTINUE READING