Identification of Cryptosporidium parvum active chemical series by Repurposing the open access malaria box.

@article{Bessoff2014IdentificationOC,
  title={Identification of Cryptosporidium parvum active chemical series by Repurposing the open access malaria box.},
  author={Kovi Bessoff and Thomas Spangenberg and Jenna E. Foderaro and Rajiv S. Jumani and G. E. Ward and Christopher D. Huston},
  journal={Antimicrobial agents and chemotherapy},
  year={2014},
  volume={58 5},
  pages={2731-9}
}
The apicomplexan parasites Cryptosporidium parvum and Cryptosporidium hominis are major etiologic agents of human cryptosporidiosis. The infection is typically self-limited in immunocompetent adults, but it can cause chronic fulminant diarrhea in immunocompromised patients and malnutrition and stunting in children. Nitazoxanide, the current standard of care for cryptosporidiosis, is only partially efficacious for children and is no more effective than a placebo for AIDS patients. Unfortunately… CONTINUE READING
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