Identification of CpxR as a positive regulator of icm and dot virulence genes of Legionella pneumophila.

@article{GalMor2003IdentificationOC,
  title={Identification of CpxR as a positive regulator of icm and dot virulence genes of Legionella pneumophila.},
  author={Ohad Gal-Mor and Gil Segal},
  journal={Journal of bacteriology},
  year={2003},
  volume={185 16},
  pages={4908-19}
}
To date, 24 Legionella pneumophila genes (icm and dot genes) have been shown to be required for intercellular growth and host cell killing. A previous report indicated that the regulation of these genes is complicated and probably involves several regulatory proteins. In this study, a genetic screen performed in Escherichia coli identified the CpxR response regulator as an activator of the L. pneumophila icmR gene. Construction of an L. pneumophila cpxR insertion mutant showed that the… CONTINUE READING

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  • J. Dong, S. Iuchi, +7 authors HL-60-derived human macrophages . Symbols
  • pneumophila wild-type strain (JR32); diamonds…
  • 2003
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