Identification of Combinatorial Patterns of Post-Translational Modifications on Individual Histones in the Mouse Brain

@inproceedings{TweedieCullen2012IdentificationOC,
  title={Identification of Combinatorial Patterns of Post-Translational Modifications on Individual Histones in the Mouse Brain},
  author={Ry Yves Tweedie-Cullen and Andrea M. Brunner and Jonas Grossmann and Safa Mohanna and David Sichau and Paolo Nanni and Christian Panse and Isabelle M Mansuy},
  booktitle={PloS one},
  year={2012}
}
Post-translational modifications (PTMs) of proteins are biochemical processes required for cellular functions and signalling that occur in every sub-cellular compartment. Multiple protein PTMs exist, and are established by specific enzymes that can act in basal conditions and upon cellular activity. In the nucleus, histone proteins are subjected to numerous PTMs that together form a histone code that contributes to regulate transcriptional activity and gene expression. Despite their importance… CONTINUE READING