Identification of Chloride Channels CLCN3 and CLCN5 Mediating the Excitatory Cl− Currents Activated by Sphingosine-1-Phosphate in Sensory Neurons

@inproceedings{Qi2018IdentificationOC,
  title={Identification of Chloride Channels CLCN3 and CLCN5 Mediating the Excitatory Cl− Currents Activated by Sphingosine-1-Phosphate in Sensory Neurons},
  author={Yanmei Qi and Norbert Mair and Kai K Kummer and Michael G Leitner and Mar{\'i}a Camprub{\'i}-Robles and Michiel Langeslag and Michaela Kress},
  booktitle={Front. Mol. Neurosci.},
  year={2018}
}
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid involved in numerous physiological and pathophysiological processes. We have previously reported a S1P-induced nocifensive response in mice by excitation of sensory neurons via activation of an excitatory chloride current. The underlying molecular mechanism for the S1P-induced chloride conductance remains elusive. In the present study, we identified two CLCN voltage-gated chloride channels, CLCN3 and CLCN5, which mediated a S1P-induced… CONTINUE READING
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