Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.

@article{Samuelson2007IdentificationOC,
  title={Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.},
  author={Andrew V Samuelson and Ryan R. Klimczak and Denis B Thompson and C. E. Carr and Gary Ruvkun},
  journal={Cold Spring Harbor symposia on quantitative biology},
  year={2007},
  volume={72},
  pages={489-97}
}
A systematic genome-wide RNA interference screen was performed in the Caenorhabditis elegans lin-15b;eri-1 strain, which has an enhanced response to double-stranded RNA including the nervous system, to identify life-span regulatory factors. In total, 16,757 genes were examined, revealing 115 gene inactivations that extended life span. A more stringent longitudinal analysis revealed 18 gene inactivations that induced the greatest increase in life span (10-90%), all of which extended life span… CONTINUE READING

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