Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain.

@article{Inatome2000IdentificationOC,
  title={Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain.},
  author={Ryoko Inatome and Tohru Tsujimura and Tomohiro Hitomi and Naoko Mitsui and Pascal Hermann and Shun'ichi Kuroda and Hirohei Yamamura and Shigeru Yanagi},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 35},
  pages={27291-302}
}
Four members of collapsin response mediator proteins (CRMPs) are thought to be involved in the semaphorin-induced growth cone collapse during neural development. Here we report the identification of a novel CRMP3-associated protein, designated CRAM for CRMP3-associated molecule, that belongs to the unc-33 gene family. The deduced amino acid sequence reveals that the CRAM gene encodes a protein of 563 amino acids, shows 57% identity with dihydropyrimidinase, and shows 50-51% identity with CRMPs… CONTINUE READING
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Identification of a Novel unc-33 Family Protein

  • H. Fujisawa, T. Kitsukawa
  • Curr. Opin. Neurobiol
  • 1998

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