Identification of CD4+CD25 high Foxp3+ T cells in ovine peripheral blood.

  title={Identification of CD4+CD25 high Foxp3+ T cells in ovine peripheral blood.},
  author={Mara S L Rocchi and Sean R Wattegedera and David J. Frew and Gary Entrican and John F. Huntley and Tom N McNeilly},
  journal={Veterinary immunology and immunopathology},
  volume={144 1-2},
Regulatory T cells (Treg) are an important subset of T lymphocytes which play a key role in maintaining peripheral immunological tolerance. The most studied subpopulation of Treg in mice and humans are natural Treg, which differentiate in the thymus and are identified by expression of CD4, high levels of IL-2Rα (CD25), and forkhead box P3 (Foxp3), a transcription factor intimately associated with Treg function. We and others have previously identified Foxp3(+) T cells in ovine tissue… CONTINUE READING

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