Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity.

  title={Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity.},
  author={Stan F J van de Graaf and Annemiete W C M van der Kemp and Dennis van den Berg and Mijke van Oorschot and Joost G. J. Hoenderop and Ren{\'e} J M Bindels},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={17 1},
Transient receptor potential vallinoid 5 (TRPV5) and TRPV6 are the most Ca2+-selective members of the TRP superfamily and are essential for active Ca2+ (re)absorption in epithelia. However, little is known about intracellular proteins that regulate the activity of these channels. This study identified BSPRY (B-box and SPRY-domain containing protein) as a novel factor involved in the control of TRPV5. The interaction between BSPRY and TRPV5 by GST pull-down and co-immunoprecipitation assays was… CONTINUE READING


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Mice lacking the epithelial calcium channel CaT1 (TRPV6) show a deficiency in intestinal calcium absorption despite high plasma levels of 1,25-dihydroxyvitamin D

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Functional expression of the epithelial Ca2 channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex

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