Identification of BRCA1/2 Founder Mutations in Southern Chinese Breast Cancer Patients Using Gene Sequencing and High Resolution DNA Melting Analysis

@inproceedings{Kwong2012IdentificationOB,
  title={Identification of BRCA1/2 Founder Mutations in Southern Chinese Breast Cancer Patients Using Gene Sequencing and High Resolution DNA Melting Analysis},
  author={Ava Kwong and Enders Kai On Ng and Chris Lei Po Wong and Fian Bic Fai Law and Tommy Au and Hong Nei Wong and Allison W. Kurian and Dee W. West and James M. Ford and Edmond Siu Kwan Ma},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Ethnic variations in breast cancer epidemiology and genetics have necessitated investigation of the spectra of BRCA1 and BRCA2 mutations in different populations. Knowledge of BRCA mutations in Chinese populations is still largely unknown. We conducted a multi-center study to characterize the spectra of BRCA mutations in Chinese breast and ovarian cancer patients from Southern China. METHODOLOGY/PRINCIPAL FINDINGS A total of 651 clinically high-risk breast and/or ovarian cancer… CONTINUE READING

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