Identification of BARD1 splice-isoforms involved in human trophoblast invasion.

  title={Identification of BARD1 splice-isoforms involved in human trophoblast invasion.},
  author={Lin Li and Marie E Cohen and Jianyu Wu and Mamadou Hady Sow and Branka Bonaci Nikolic and Paul Bischof and Irmgard Irminger-Finger},
  journal={The international journal of biochemistry & cell biology},
  volume={39 9},
The tumor suppressor protein BARD1, originally discovered as BRCA1-binding protein, acts in conjunction with BRCA1 as ubiquitin ligase. BARD1 and BRCA1 form a stable heterodimer and dimerization, which is required for most tumor suppressor functions attributed to BRCA1. In addition, BARD1 has BRCA1-independent functions in apoptosis, and a role in control of tissue homeostasis was suggested. However, cancer-associated mutations of BARD1 are rare; on the contrary, overexpression of truncated… CONTINUE READING


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