Identification of B- and T-cell epitopes of BB, a carrier protein derived from the G protein of Streptococcus strain G148.

@article{Goetsch2003IdentificationOB,
  title={Identification of B- and T-cell epitopes of BB, a carrier protein derived from the G protein of Streptococcus strain G148.},
  author={Liliane Goetsch and Jean François Haeuw and Thierry Champion and Christine Lacheny and Thien N'Guyen and Alain Beck and Nathalie Corvaia},
  journal={Clinical and diagnostic laboratory immunology},
  year={2003},
  volume={10 1},
  pages={125-32}
}
Most conventional vaccines consist of killed organisms or purified antigenic proteins. Such molecules are generally poorly immunogenic and need to be coupled to carrier proteins. We have identified a new carrier molecule, BB, derived from the G protein of Streptococcus strain G148. We show that BB is able to induce strong antibody responses when conjugated to peptides or polysaccharides. In order to localize T and B cell epitopes in BB and match them with the albumin-binding region of the… CONTINUE READING