Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes.

@article{Stephenson2009IdentificationOA,
  title={Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes.},
  author={Linda M. Stephenson and Brian C. Miller and Aylwin Ng and Jason Eisenberg and Zijiang Zhao and Ken Cadwell and Daniel B. Graham and Noboru Mizushima and Ramnik Xavier and Herbert W Virgin and Wojciech Swat},
  journal={Autophagy},
  year={2009},
  volume={5 5},
  pages={625-35}
}
Autophagy is implicated in many functions of mammalian cells such as organelle recycling, survival and differentiation, and is essential for the maintenance of T and B lymphocytes. Here, we demonstrate that autophagy is a constitutive process during T cell development. Deletion of the essential autophagy genes Atg5 or Atg7 in T cells resulted in decreased thymocyte and peripheral T cell numbers, and Atg5-deficient T cells had a decrease in cell survival. We employed functional-genetic and… CONTINUE READING

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