Identification of Aph1, a Phosphate-Regulated, Secreted, and Vacuolar Acid Phosphatase in Cryptococcus neoformans

@inproceedings{Lev2014IdentificationOA,
  title={Identification of Aph1, a Phosphate-Regulated, Secreted, and Vacuolar Acid Phosphatase in Cryptococcus neoformans},
  author={Sophie Lev and Ben Crossett and So Young Cha and Desmarini Desmarini and Cecilia W. P. Li and Methee Chayakulkeeree and Christabel Frewen Wilson and Peter R. Williamson and Tania C Sorrell and Julianne Teresa Djordjevic},
  booktitle={mBio},
  year={2014}
}
UNLABELLED Cryptococcus neoformans strains isolated from patients with AIDS secrete acid phosphatase, but the identity and role of the enzyme(s) responsible have not been elucidated. By combining a one-dimensional electrophoresis step with mass spectrometry, a canonically secreted acid phosphatase, CNAG_02944 (Aph1), was identified in the secretome of the highly virulent serotype A strain H99. We created an APH1 deletion mutant (Δaph1) and showed that Δaph1-infected Galleria mellonella and mice… CONTINUE READING
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Identification of genes involved in the phosphate metabolism in Cryptococcus neoformans.

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