Identification of Amino Acid Residues of the T-Cell Epitope of Mycobacterium tuberculosis α Antigen Critical for Vβ11+ Th1 Cells

@inproceedings{Kariyone1999IdentificationOA,
  title={Identification of Amino Acid Residues of the T-Cell Epitope of Mycobacterium tuberculosis α Antigen Critical for Vβ11+ Th1 Cells},
  author={A I Kariyone and Kazue Higuchi and Shigeki Yamamoto and Ai Nagasaka-Kametaka and Mamoru Harada and Akio Takahashi and Nobuyuki Harada and Kazumasa Ogasawara and Kiyoshi Takatsu},
  year={1999}
}
Stimulation of Mycobacterium tuberculosis-primed lymph node cells from C57BL/6 mice with α antigen (also known as antigen 85B and MPT59) induced cell proliferation, production of interleukin 2 and gamma interferon, and expansion of Vβ11+ CD4+ T cells in conjunction with antigen-presenting cells in an I-Ab-restricted manner. Using a series of 15-amino-acid peptides that overlapped each other by 5 amino acids and spanned the mature α antigen, we identified the antigenic epitope for α antigen… CONTINUE READING

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