Identification of Actinobacillus pleuropneumoniae genes important for survival during infection in its natural host.

@article{Sheehan2003IdentificationOA,
  title={Identification of Actinobacillus pleuropneumoniae genes important for survival during infection in its natural host.},
  author={Brian J Sheehan and Janine T Boss{\'e} and Amanda J. Beddek and Andrew N. Rycroft and J. Simon Kroll and Paul R Langford},
  journal={Infection and immunity},
  year={2003},
  volume={71 7},
  pages={3960-70}
}
Actinobacillus pleuropneumoniae is a strict respiratory tract pathogen of swine and is the causative agent of porcine pleuropneumonia. We have used signature-tagged mutagenesis (STM) to identify genes required for survival of the organism within the pig. A total of 2,064 signature-tagged Tn10 transposon mutants were assembled into pools of 48 each, and used to inoculate pigs by the endotracheal route. Out of 105 mutants that were consistently attenuated in vivo, only 11 mutants showed a >2-fold… CONTINUE READING

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