Identification of ATP synthase beta subunit (ATPB) on the cell surface as a non-small cell lung cancer (NSCLC) associated antigen

@inproceedings{Lu2008IdentificationOA,
  title={Identification of ATP synthase beta subunit (ATPB) on the cell surface as a non-small cell lung cancer (NSCLC) associated antigen},
  author={Ze-jun Lu and Qi-fang Song and Sa-sa Jiang and Qi Song and Wei Wang and Gao-hua Zhang and B. Kan and Lan-tu Gou and Lijuan Chen and Feng Luo and Zhiyong Qian and Jing Yang and Yu-quan Wei},
  booktitle={BMC Cancer},
  year={2008}
}
Antibody-based immuneotherapy has achieved some success for cancer. But the main problem is that only a few tumor-associated antigens or therapeutic targets have been known to us so far. It is essential to identify more immunogenic antigens (especially cellular membrane markers) for tumor diagnosis and therapy. The membrane proteins of lung adenocarcinoma cell line A549 were used to immunize the BALB/c mice. A monoclonal antibody 4E7 (McAb4E7) was produced with hybridoma technique. MTT cell… CONTINUE READING
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