Identification of ATP-synthase as a novel intracellular target for microcystin-LR.

@article{Mikhailov2003IdentificationOA,
  title={Identification of ATP-synthase as a novel intracellular target for microcystin-LR.},
  author={Andrey Mikhailov and Ann-Sofi H{\"a}rm{\"a}l{\"a}-Brask{\'e}n and Jukka Hellman and Jussi Meriluoto and John E. Eriksson},
  journal={Chemico-biological interactions},
  year={2003},
  volume={142 3},
  pages={
          223-37
        }
}
Microcystins (MCs) are a group of closely related cyclic heptapeptides produced by a variety of common cyanobacteria. These are potent and highly specific hepatotoxins, the toxicity of which is based upon their inhibition of type-1 (PP1) and type-2A (PP2A) protein phosphatases. Apart from protein phosphatases, it is not known whether these phosphatase-inhibiting peptides could bind any other cellular proteins. We wanted to determine whether any possible unknown MC-adducts could explain the… CONTINUE READING
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