Identification of ATIC as a Novel Target for Chemoradiosensitization.


PURPOSE Mutations in the gene encoding 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), a bifunctional enzyme that catalyzes the final 2 steps of the purine de novo biosynthetic pathway, were identified in a subject referred for radiation sensitivity testing. Functional studies were performed to determine whether… (More)
DOI: 10.1016/j.ijrobp.2017.08.033