Identification of ASAH1 as a susceptibility gene for familial keloids.

  title={Identification of ASAH1 as a susceptibility gene for familial keloids.},
  author={Regie P. Lyn Santos-Cortez and Ying Hu and Fanyue Sun and Fairouz Benahmed-Miniuk and Jian Tao and Jitendra K Kanaujiya and Samuel Adesina Ademola and Solomon Olufemi Fadiora and Victoria Odesina and Deborah A. Nickerson and Michael J Bamshad and Peter Babatunde Olaitan and O. Abimbola Oluwatosin and Suzanne M. Leal and Ernst J. Reichenberger},
  journal={European journal of human genetics : EJHG},
  volume={25 10},
Keloids result from abnormal proliferative scar formation with scar tissue expanding beyond the margin of the original wound and are mostly found in individuals of sub-Saharan African descent. The etiology of keloids has not been resolved but previous studies suggest that keloids are a genetically heterogeneous disorder. Although possible candidate genes have been suggested by genome-wide association studies using common variants, by upregulation in keloids or their involvement in syndromes… CONTINUE READING
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