Identification of APC gene mutations in Italian adenomatous polyposis coli patients by PCR-SSCP analysis.

@article{Varesco1993IdentificationOA,
  title={Identification of APC gene mutations in Italian adenomatous polyposis coli patients by PCR-SSCP analysis.},
  author={Liliana Varesco and Viviana Gismondi and Reade William James and Margaret Robertson and Paola Grammatico and Joanna Groden and Lucia Casarino and L De Benedetti and Anna Bafico and Lucio Bertario},
  journal={American journal of human genetics},
  year={1993},
  volume={52 2},
  pages={
          280-5
        }
}
The APC gene is a putative human tumor-suppressor gene responsible for adenomatous polyposis coli (APC), an inherited, autosomal dominant predisposition to colon cancer. It is also implicated in the development of sporadic colorectal tumors. The characterization of APC gene mutations in APC patients is clinically important because DNA-based tests can be applied for presymptomatic diagnosis once a specific mutation has been identified in a family. Moreover, the identification of the spectrum of… CONTINUE READING

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