Identification of ALK in Thinness
@article{Orthofer2020IdentificationOA, title={Identification of ALK in Thinness}, author={Michael Orthofer and Armand Valsesia and Reedik M{\"a}gi and Qiao-Ping Wang and Evgenii O. Tretiakov and Josef M. Penninger}, journal={Cell}, year={2020}, volume={181}, pages={1246-1262.e22} }
27 Citations
Deciphering the genetics of resistance to weight gain
- BiologyNature Reviews Endocrinology
- 2020
Functional knockout experiments in mice showed that aLK in the paraventricular nucleus was key for resisting weight gain when mice were fed a high-fat diet, and hence thinness, and this work puts the white adipose tissue in the centre of the focus of finding solutions for obesity in humans.
Genetics of Obesity: What We Have Learned Over Decades of Research
- Biology, MedicineObesity
- 2021
There is a genetic component to human obesity that accounts for 40% to 50% of the variability in body weight status but that is lower among normal weight individuals (about 30%) and substantially…
The genetics of obesity: from discovery to biology
- BiologyNature reviews. Genetics
- 2021
The current understanding of the genetic underpinnings of monogenic and polygenic obesity is summarized, highlighting the commonalities revealed by recent studies and discussing the implications for treatment and prediction of obesity risk.
A hypothalamic pathway for Augmentor α-controlled body weight regulation.
- Biology, MedicineProceedings of the National Academy of Sciences of the United States of America
- 2022
Experiments are presented demonstrating that the physiological ligands of Alk function in the hypothalamus to control body weight, offering new therapeutic treatments for metabolic diseases and cancer.
Strategies to Understand the Weight‐Reduced State: Genetics and Brain Imaging
- BiologyObesity
- 2021
The use of cell biology, genetics, and imaging techniques that are being used to begin understanding why weight regain is the normal response to dieting are reviewed.
Metabolic (dysfunction)-associated fatty liver disease in individuals of normal weight
- Medicine, BiologyNature Reviews Gastroenterology & Hepatology
- 2022
This framework provides a conceptual schema for interrogating the MAFLD phenotype in individuals of normal weight that can translate to novel approaches for diagnosis and patient care and provide insights into their metabolic health and metabolic adaptation.
Mice Lacking Gpr75 are Hypophagic and Thin
- Biology, MedicineDiabetes, metabolic syndrome and obesity : targets and therapy
- 2022
It is suggested that inhibiting GPR75 in obese humans may safely decrease energy intake and body fat while improving glucose tolerance and insulin sensitivity as healthy-appearing adults.
Female Mice with Selenocysteine tRNA Deletion in Agrp Neurons Maintain Leptin Sensitivity and Resist Weight Gain While on a High-Fat Diet
- BiologyInternational journal of molecular sciences
- 2021
It is found that female TrspAgrpKO mice gain less weight while on a high-fat diet, which occurs due to changes in adipose tissue activity, and male mice were unaffected, highlighting the sexually dimorphic influence of selenium on neurobiology and energy homeostasis.
The central melanocortin system and human obesity
- BiologyJournal of molecular cell biology
- 2020
The advances in the identification of human genetic variants that cause obesity via mechanisms that affect the central melanocortin system are reviewed, which have provided rational targets for treatment of genetically susceptible patients.
Associations between Genotype–Diet Interactions and Weight Loss—A Systematic Review
- MedicineNutrients
- 2020
No evidence was found that genotype–diet interaction is a main determinant of obesity treatment success, but this needs to be addressed in future studies.
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