Identification of ABCG2 dysfunction as a major factor contributing to gout.

@article{Matsuo2011IdentificationOA,
  title={Identification of ABCG2 dysfunction as a major factor contributing to gout.},
  author={Hirotaka Matsuo and Tappei Takada and Kimiyoshi Ichida and Takahiro J Nakamura and Akiyoshi Nakayama and Yuzo Takada and Chisa Okada and Yonekiti Sakurai and Takamichi Hosoya and Yoshikatsu Kanai and Hiroaki Suzuki and Nariyoshi Shinomiya},
  journal={Nucleosides, nucleotides & nucleic acids},
  year={2011},
  volume={30 12},
  pages={
          1098-104
        }
}
The ATP-binding cassette, subfamily G, member 2 gene ABCG2/BCRP locates in a gout-susceptibility locus (MIM 138900) on chromosome 4q. Recent genome-wide association studies also showed that the ABCG2 gene relates to serum uric acid levels and gout. Since ABCG2 is also known as a transporter of nucleotide analogs that are structurally similar to urate, and is an exporter that has common polymorphic reduced functionality variants, ABCG2 could be a urate secretion transporter and a gene causing… CONTINUE READING
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