Identification of 8-dehydrocholesterol (cholesta-5,8-dien-3 beta-ol) in patients with Smith-Lemli-Opitz syndrome.

@article{Batta1995IdentificationO8,
  title={Identification of 8-dehydrocholesterol (cholesta-5,8-dien-3 beta-ol) in patients with Smith-Lemli-Opitz syndrome.},
  author={AshokK. Batta and G. Stephen Tint and Sarah Shefer and Dianne N. Abuelo and Gerald Salen},
  journal={Journal of lipid research},
  year={1995},
  volume={36 4},
  pages={
          705-13
        }
}
Cholesta-5,8-dien-3 beta-ol (8-dehydrocholesterol) and cholesta-5,7-dien-3 beta-ol (7-dehydrocholesterol) were isolated from the fecal neutral sterol fraction from homozygotes with Smith-Lemli-Opitz syndrome. The structures of the sterols were conclusively established from their mass spectra and 1H and 13C nuclear magnetic resonance spectra. It is probable that 8-dehydrocholesterol arises from 7-dehydrocholesterol and is not a direct precursor of cholesterol. 

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 24 CITATIONS

Similar Papers

Loading similar papers…