Identification of 7ξ-hydroxytetrahydrocortisol and 7ξ-hydroxytetrahydrocortsone from urine of newborn baboons ( papio papio )

  title={Identification of 7$\xi$-hydroxytetrahydrocortisol and 7$\xi$-hydroxytetrahydrocortsone from urine of newborn baboons (
 papio papio
  author={Gerald J. Pepe and John D. Ownsley},
Two highly polar, unconjugated metabolltes of tetrahydrocortisol and tetrahydrocortisone, which had been shown previously to account for greater than 40% of [14C]cortisol (F) administered to baboon neonates, were isolated from urine of a term newborn animal. Metabolites were extracted with ethyl acetate, purified by sequential paper chromatography and crystallization, and identified by chemical and biochemical procedures. Both metabolites of F are 5beta-pregnanes with a hydroxyl of unknown… 
1 Citations
The effects of estrogen on cortisol metabolism in female baboons
The suggestion that estrogen is a major factor which alters F metabolism and increases serum CBC in baboon gestation is suggested, however, additional factors are operative in primate pregnancy which maintain PR and MCR of F at levels similar to those of nonpregnant baboons.


The identification of 3α,6β,11β,17,21-pentahydroxy-5β-pregnan-20-one (6β-hydroxy-THF)-the major urinary steroid of the baboon (Papio papio)
Abstract The identification of 3α,6β,11β,17,21-pentahydroxy-5β-pregnan-20-one (6β-hydroxy-THF) from the urine of the baboon ( Papio papio ) is described. Steroids were extracted from urine with
The metabolism of cortisol by term baboon neonates (Papio papio).
The low F production rate, reduced glucuronoside formation, and increase in highly polar compounds relative to nonpregnant adults resemble the situation in humans, but is compensated for, quantitatively, by highly polar metabolites, which are extractable from baboon urine with ethyl acetate but are nonextractable from the urine fo human neonates.
Cortisol metabolism in female baboons (Papio papio).
The metabolism of iv administered 14C-cortisol (F) by mature female baboons was compared with that reported for humans and thirty-five percent of the glucuronoside fraction was less polar than cortisone indicating extensive side-chain cleavage.
Adrenocortical steroid metabolism in newborn infants. II. Urinary excretion of 6beta-hydroxycortisol and other polar metabolites.
It appears that the normal infant metabolizes cortisol efficiently, but that degradation pathways of minor quantitative importance in the adult are more extensively used during the first postnatal week.
Metabolism of cortisol by the human newborn infant.
14C-cortisol was administered to 2 newborn infants and 1 adult, and the pattern of urinary metabolites analyzed and compared, finding that in the adult control the distribution of the radioactivity in the unconjugated, glucuronide and sulfat...
6beta-Hydroxycortisol and other polar corticosteroids: measurement and significance in human urine.
A detailed description of extraction and paper ehromatographie techniques for themeasurement of urinary 6β-hydroxycortisol is presented, together with experimental data from which this and other
The catalytic reduction of 3-beta-hydroxyandrost-5-en-17-one with tritium. The distribution and orientation of label in the product (1).
6β-Bromination and 6β-methoxylation was carried out on VI with little loss of label, indicating that the tritium at C-6 was alpha orientated, and chemical and kinetic experiments established that the additional label was at C -7α.
Catabolic regulation of blood cortisol in premature and term baboon neonates.
It is concluded that extrahepatic 11β-hydroxysteroid dehydrogenase is important in achieving a low F:E ratio in fetal blood and is likely to account for the increased fetal blood F concentrations prior to parturition.