Identification of 7ξ-hydroxytetrahydrocortisol and 7ξ-hydroxytetrahydrocortsone from urine of newborn baboons ( papio papio )

@article{Pepe1978IdentificationO7,
  title={Identification of 7$\xi$-hydroxytetrahydrocortisol and 7$\xi$-hydroxytetrahydrocortsone from urine of newborn baboons (
 
 papio papio
 
 )},
  author={Gerald J. Pepe and John D. Ownsley},
  journal={Steroids},
  year={1978},
  volume={31},
  pages={501-510}
}
Two highly polar, unconjugated metabolltes of tetrahydrocortisol and tetrahydrocortisone, which had been shown previously to account for greater than 40% of [14C]cortisol (F) administered to baboon neonates, were isolated from urine of a term newborn animal. Metabolites were extracted with ethyl acetate, purified by sequential paper chromatography and crystallization, and identified by chemical and biochemical procedures. Both metabolites of F are 5beta-pregnanes with a hydroxyl of unknown… 
1 Citations
The effects of estrogen on cortisol metabolism in female baboons
TLDR
The suggestion that estrogen is a major factor which alters F metabolism and increases serum CBC in baboon gestation is suggested, however, additional factors are operative in primate pregnancy which maintain PR and MCR of F at levels similar to those of nonpregnant baboons.

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