Identification of 5-HT2 receptors, alpha 1-adrenoceptors and amine release sites in rat brain by autoradiography with [125I]7-amino-8-iodo-ketanserin.

Abstract

Using autoradiographical techniques, we found that [125I]7-amino-8-iodo-ketanserin ([125I]AMIK) labelled with high affinity 5-HT2 receptors, alpha 1-adrenoceptors and sites involved in the release of biogenic amines and metabolites. The three binding sites for [125I]AMIK were identified by using selective inhibitors, i.e. BW 501 for 5-HT2 receptors… (More)

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