Identification of 3' alpha-hs4, a novel Ig heavy chain enhancer element regulated at multiple stages of B cell differentiation.

@article{Michaelson1995IdentificationO3,
  title={Identification of 3' alpha-hs4, a novel Ig heavy chain enhancer element regulated at multiple stages of B cell differentiation.},
  author={Jennifer S. Michaelson and Sabrina Giannini and Barbara K. Birshtein},
  journal={Nucleic acids research},
  year={1995},
  volume={23 6},
  pages={975-81}
}
In addition to E mu, several elements downstream of the IgH cluster, i.e. 3' of the C alpha gene, are involved in regulating IgH gene rearrangement and expression. This entire downstream regulatory region was shown to be deleted in the mutant myeloma cell line, LP1.2. The deletion encompasses approximately 34 kb and is presumably responsible for the reduced levels of IgH expression in this cell line. An additional regulatory element, included in the LP1.2 deletion, was identified by… CONTINUE READING

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