Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

  title={Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array},
  author={Rosalind A. Eeles and Ali Amin Al Olama and Sara Benlloch and Edward J. Saunders and Daniel A. Leongamornlert and Malgorzata Tymrakiewicz and Maya Ghoussaini and Craig Luccarini and Joe Dennis and Sarah Jugurnauth-Little and Tokhir Dadaev and David E. Neal and Freddie Hamdy and Jenny L Donovan and Ken W Muir and Graham G. Giles and Gianluca Severi and Fredrik Wiklund and Henrik Gronberg and Christopher A. Haiman and Fredrick R Schumacher and Brian E. Henderson and Loic Le Marchand and Sara Lindstrom and Peter Kraft and David J. Hunter and Susan M. Gapstur and Stephen J. Chanock and Sonja I. Berndt and Demetrius Albanes and Gerald L. Andriole and Johanna Schleutker and Maren Weischer and Frederico Canzian and Elio Riboli and Timothy J Key and Ruth C. Travis and Daniele Campa and Sue Ann Ingles and Esther M John and Richard B Hayes and Paul D. P. Pharoah and Nora Pashayan and Kay-tee Khaw and Janet L. Stanford and Elaine A Ostrander and Lisa Beth Signorello and Stephen N. Thibodeau and Dan Schaid and Christiane Maier and Walther Vogel and Adam S. Kibel and Cezary Cybulski and Jan A. Lubiński and Lisa A. Cannon-Albright and Hermann Brenner and Jong Y. Park and Radka Kaneva and Jyotsna Batra and Amanda B Spurdle and Judith Ann Clements and Manuel R. Teixeira and Ed Dicks and Andrew Lee and Alison M. Dunning and Caroline Baynes and Don Conroy and Melanie J Maranian and Shahana Ahmed and Koveela Govindasami and Michelle Guy and Rosemary A. Wilkinson and Emma J. Sawyer and A Christian Morgan and David Paul Dearnaley and Alan H. Horwich and Robert A Huddart and Vincent Khoo and Christopher C. Parker and Nicholas J Van As and Christopher R J Woodhouse and Alan Thompson and Tim Dudderidge and Chris Ogden and Colin S Cooper and Artitaya Lophatananon and Angela Cox and Melissa C. Southey and John L. Hopper and Dallas English and M. Z. Y. Aly and J. Patrik Adolfsson and Jiangfeng Xu and S{\'i}qun Lilly Zheng and Meredith Yeager and Rudolf Kaaks and W Ryan Diver and Mia M Gaudet and Mariana C. Stern and R. Prieto Corral and Amit D. Joshi and Ahva Shahabi and Tiina A Wahlfors and Teuvo L. J. Tammela and Anssi Auvinen and Jarmo R Virtamo and Peter Klarskov and B\orge G. Nordestgaard and Martin Andreas R\oder and Sune Fallgaard Nielsen and Stig Egil Bojesen and A Mohammed Siddiq and L M FitzGerald and Suzanne Kolb and Erika M. Kwon and Danielle M. Karyadi and William J. Blot and Wei Zheng and Qiuyin Cai and Shannon K. McDonnell and Antje E. Rinckleb and Bettina F Drake and Graham C Colditz and Dominika Wokolorczyk and Robert A. Stephenson and Craig Carl Teerlink and Heiko Muller and Dietrich Rothenbacher and Thomas A. Sellers and Hui-Yi Lin and Chavdar Slavov and Vanio Mitev and Felicity A. Lose and Srilakshmi Srinivasan and Sofia Maia and Paula Paulo and Ethan Lange and Kathleen A Cooney and Antonis C. Antoniou and Daniel D Vincent and François Bacot and Daniel C. Tessier and Zsofia Kote-Jarai and Douglas F. Easton},
  journal={Nature Genetics},
Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10−8). More than 70 prostate cancer susceptibility loci, explaining ∼30… CONTINUE READING
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Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk

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