Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline

@inproceedings{Weinberg2007IdentificationO2,
  title={Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline},
  author={Zasha Weinberg and Jeffrey E. Barrick and Zizhen Yao and Adam Roth and Jane N. Kim and Jeremy Gore and Joy Xin Wang and Elaine R. Lee and Kirsten F. Block and Narasimhan Sudarsan and Shane J. Neph and Martin Tompa and Walter L. Ruzzo and Ronald R. Breaker},
  booktitle={Nucleic acids research},
  year={2007}
}
We applied a computational pipeline based on comparative genomics to bacteria, and identified 22 novel candidate RNA motifs. We predicted six to be riboswitches, which are mRNA elements that regulate gene expression on binding a specific metabolite. In separate studies, we confirmed that two of these are novel riboswitches. Three other riboswitch candidates are upstream of either a putative transporter gene in the order Lactobacillales, citric acid cycle genes in Burkholderiales or molybdenum… CONTINUE READING
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