Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA.

@article{Kim2008IdentificationO2,
  title={Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA.},
  author={Soong-Hoon Kim and J. S. Tokarski and Kenneth J Leavitt and Brian E Fink and Mark E Salvati and Robert V Moquin and Mary T. Obermeier and George L. Trainor and Gregory G Vite and Linda K Stadnick and Jonathan S Lippy and Dan You and Matthew V. Lorenzi and Ping Chen},
  journal={Bioorganic & medicinal chemistry letters},
  year={2008},
  volume={18 2},
  pages={634-9}
}
2-Amino-5-(thioaryl)thiazoles are potent inhibitors of TrkA (e.g., 20h, TrkA IC(50)=0.6 nM) that show anti-proliferative effect in cellular assays. A proposed inhibitor binding mode to TrkA active site is consistent with key SAR observations. 

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…