Identification of 2′,3′-cGMP as an intermediate of RNA catalytic cleavage by binase and evaluation of its biological action

@article{Sokurenko2015IdentificationO2,
  title={Identification of 2′,3′-cGMP as an intermediate of RNA catalytic cleavage by binase and evaluation of its biological action},
  author={Yu. V. Sokurenko and Pavel V Zelenikhin and Vera V. Ulyanova and Alexey I. Kolpakov and Delphine Muller and Olga N. Ilinskaya},
  journal={Russian Journal of Bioorganic Chemistry},
  year={2015},
  volume={41},
  pages={31-36}
}
Binase, the RNAse from Bacillus pumilus, is an endonuclease that cleaves the phosphodiester bond between the 3′-guanyl residue and 5′-OH residue of an adjacent nucleotide, with the formation of a corresponding intermediate, 2′,3′-cGMP. Subsequent hydrolysis of 2′,3′-cGMP into a 3′-phosphate is highly specific and proceeds slowly. Thus, a question arises in respect to the time interval that this positional isomer exists during catalytic cleavage of RNA by binase, and whether it may contribute to… CONTINUE READING
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The Enzymes, New York

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