Identification of 10 cowpox virus proteins that are necessary for induction of hemorrhagic lesions (red pocks) on chorioallantoic membranes.

@article{Xu2014IdentificationO1,
  title={Identification of 10 cowpox virus proteins that are necessary for induction of hemorrhagic lesions (red pocks) on chorioallantoic membranes.},
  author={Zhiyong Xu and Dimitrios Zikos and Aistė Tamo{\vs}iūnaitė and Robert Klopfleisch and Nikolaus Osterrieder and Bernd Karsten Tischer},
  journal={Journal of virology},
  year={2014},
  volume={88 15},
  pages={8615-28}
}
UNLABELLED Cowpox viruses (CPXV) cause hemorrhagic lesions ("red pocks") on infected chorioallantoic membranes (CAM) of embryonated chicken eggs, while most other members of the genus Orthopoxvirus produce nonhemorrhagic lesions ("white pocks"). Cytokine response modifier A (CrmA) of CPXV strain Brighton Red (BR) is necessary but not sufficient for the induction of red pocks. To identify additional viral proteins involved in the induction of hemorrhagic lesions, a library of single-gene CPXV… CONTINUE READING

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