Identification of β-haemolysin-encoding genes in Streptococcus anginosus.

  title={Identification of β-haemolysin-encoding genes in Streptococcus anginosus.},
  author={Daniela Asam and Stefanie Mauerer and Ellen Walheim and Barbara Spellerberg},
  journal={Molecular oral microbiology},
  volume={28 4},
Streptococcus anginosus is an emerging pathogen, but little is known about its virulence factors. To detect the genes responsible for β-haemolysis we performed genomic mutagenesis of the β-haemolytic S. anginosus type strain ATCC 12395 using the vector pGhost9:ISS1. Integration site analysis of 15 non-haemolytic mutants identified a gene cluster with high homology to the genes of the streptolysin S (SLS) encoding sag gene cluster of S. pyogenes. The gene cluster harbours 10 open reading frames… CONTINUE READING