Identification of [PtCl2(phen)] binding modes in amyloid-β peptide and the mechanism of aggregation inhibition.

@article{Ma2011IdentificationO,
  title={Identification of [PtCl2(phen)] binding modes in amyloid-β peptide and the mechanism of aggregation inhibition.},
  author={Guolin Ma and Fan Yen Huang and Xuewei Pu and Liangyuan Jia and Tao Jiang and Lianzhi Li and Yangzhong Liu},
  journal={Chemistry},
  year={2011},
  volume={17 41},
  pages={11657-66}
}
Platinum phenanthroline complexes inhibit amyloid-β (Aβ) aggregation and reduce Aβ-caused neurotoxicity [Proc. Natl. Acad. Sci., 2008, 105, 6813-6818]. In this study, we investigated the interactions of Aβ(1-16) with [PtCl(2)(phen)] (phen=1,10-phenanthroline) using HPLC, ESI-MS, and NMR spectroscopy , and characterized the identity of products using tandem mass spectrometry. Results indicated that the phenanthroline ligand could induce noncovalent interactions between Aβ peptide and platinum… CONTINUE READING