Identification in transgenic animals of the Drosophila decapentaplegic sequences required for embryonic dorsal pattern formation.

@article{Hoffmann1987IdentificationIT,
  title={Identification in transgenic animals of the Drosophila decapentaplegic sequences required for embryonic dorsal pattern formation.},
  author={Francis Michael Hoffmann and William F Goodman},
  journal={Genes & development},
  year={1987},
  volume={1 6},
  pages={615-25}
}
Mutant alleles of the Drosophila decapentaplegic (dpp) gene affect embryonic dorsal-ventral pattern formation, larval viability, and adult cuticle formation from the imaginal disks. The dpp DNA required for this array of functions spans almost 50 kb. We report that the embryonic lethal, ventralizing alleles of the dpp gene are rescued in transgenic animals by an 8-kb fragment of the wild-type dpp DNA. Full rescue, from embryonic lethality to adult viability, is obtained in two situations: in… CONTINUE READING

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