Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17 alpha-hydroxylase.

@article{Krohn1992IdentificationBM,
  title={Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17 alpha-hydroxylase.},
  author={Kai J. E. Krohn and Raivo Uibo and E. Aavik and P{\"a}rt Peterson and K Savilahti},
  journal={Lancet},
  year={1992},
  volume={339 8796},
  pages={770-3}
}
Idiopathic Addison's disease is characterised by a progressive failure in the synthesis of all classes of steroid hormones and by an immune response against the steroid-producing cells of the adrenal cortex; the nature of the adrenal autoantigens is not known. We have used molecular cloning and sequencing to identify the target antigens. We screened a human… CONTINUE READING