Identification by gene deletion analysis of barB as a negative regulator controlling an early process of virginiamycin biosynthesis in Streptomyces virginiae

@article{Matsuno2003IdentificationBG,
  title={Identification by gene deletion analysis of barB as a negative regulator controlling an early process of virginiamycin biosynthesis in Streptomyces virginiae},
  author={Kiyoshi Matsuno and Yasuhiro Yamada and C. Lee and Takuya Nihira},
  journal={Archives of Microbiology},
  year={2003},
  volume={181},
  pages={52-59}
}
The Streptomyces virginiae γ-butyrolactone autoregulator virginiae butanolide is a low-molecular-weight Streptomyces hormone eliciting virginiamycin biosynthesis through its binding to the specific receptor protein, BarA. Immediately downstream of barA lies barB, the transcription of which is tightly repressed by BarA in the absence of virginiae butanolide and derepressed in its presence. Thus, BarB is next to BarA on the virginiae butanolide-BarA signaling cascade. An in-frame 279-bp deletion… CONTINUE READING
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Identification of the varR gene as a transcriptional regulator of virginiamycin S resistance in Streptomyces virginiae

  • W Namwat, Lee C-K, H Kinoshita, Y Yamada, T Nihira
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